abstract：:Postherpetic neuralgia (PHN) is a debilitating chronic pain condition, yet there is a lack of knowledge regarding underlying brain activity. Here we identify brain regions involved in spontaneous pain of PHN (n=11) and determine its modulation with Lidoderm therapy (patches of 5% lidocaine applied to the PHN affected ...

journal_title：Pain

authors： Geha PY,Baliki MN,Chialvo DR,Harden RN,Paice JA,Apkarian AV

更新日期：2007-03-01 00:00:00

abstract：:Noxious C-fibre stimulation produces increased sensitivity within the injured area (primary hyperalgesia), and a surrounding zone of secondary hyperalgesia. As significant changes in nociceptive processing occur during development, we compared C-fibre induced primary and secondary hyperalgesia in rat pups aged 3, 10 a...

journal_title：Pain

authors： Walker SM,Meredith-Middleton J,Lickiss T,Moss A,Fitzgerald M

更新日期：2007-03-01 00:00:00

abstract：:Although cognitive-behavioral therapies (CBT) have been demonstrated to be effective for a variety of chronic pain problems, patients vary in their response and little is known about patient characteristics that predict or moderate treatment effects. Furthermore, although cognitive-behavioral theory posits that change...

journal_title：Pain

authors： Turner JA,Holtzman S,Mancl L

更新日期：2007-02-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (Cdk5) is a unique member of the CDK family. It is predominantly expressed in postmitotic neurons and has been implicated in neuronal plasticity. The present study showed that Cdk5 and p35 were expressed in primary sensory and dorsal horn neurons, while p25, an N-terminal truncated derivative...

journal_title：Pain

authors： Yang YR,He Y,Zhang Y,Li Y,Li Y,Han Y,Zhu H,Wang Y

更新日期：2007-01-01 00:00:00

abstract：:Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Intriguingly, several reports showed that capsaicin also inhibits Na+ currents but the mechanisms remain unclear. To explore this non-TRPV1 action we applied capsaicin to HEK293 cells stably expressing inactivation-deficient rat skele...

journal_title：Pain

authors： Wang SY,Mitchell J,Wang GK

更新日期：2007-01-01 00:00:00

abstract：:Biopsychosocial models of chronic pain that recognize psychological and environmental factors as important aspects of adjustment to pain have been proposed for understanding chronic pain and related suffering in persons with multiple sclerosis (MS), but such models have not been empirically tested. The objective of th...

journal_title：Pain

authors： Osborne TL,Jensen MP,Ehde DM,Hanley MA,Kraft G

更新日期：2007-01-01 00:00:00

abstract：:Histamine, substance P, serotonin and bradykinin were applied by iontophoresis to lesional and visually non-lesional skin of 14 patients with atopic dermatitis, and normal skin of 15 healthy volunteers. Itch could be evoked by light stroking of skin with a cotton swab (alloknesis) in all lesional skin sites, but not i...

journal_title：Pain

authors： Hosogi M,Schmelz M,Miyachi Y,Ikoma A

更新日期：2006-12-15 00:00:00

abstract：:Mechanisms of chronic pain, including neuropathic pain, are poorly understood. Upregulation of voltage-gated calcium channel (VGCC) alpha2delta1 subunit (Ca(v)alpha2delta1) in sensory neurons and dorsal spinal cord by peripheral nerve injury has been suggested to contribute to neuropathic pain. To investigate the mech...

journal_title：Pain

authors： Li CY,Zhang XL,Matthews EA,Li KW,Kurwa A,Boroujerdi A,Gross J,Gold MS,Dickenson AH,Feng G,Luo ZD

更新日期：2006-11-01 00:00:00

abstract：:Despite frequent targeting of health beliefs in pediatric chronic pain treatment interventions, there are currently no reliable and valid self-efficacy measures for children with chronic pain and their parents. The current study examined the psychometric properties of parent and child versions of a self-efficacy measu...

journal_title：Pain

authors： Bursch B,Tsao JC,Meldrum M,Zeltzer LK

更新日期：2006-11-01 00:00:00

abstract：:The present study investigated whether the level of cognitive impairment (CI) affects acute pain behavior and how it is manifested. Participants were 159 individuals (mean age 42+/-12), 121 with CI (divided into four groups according to the level of CI: mild, moderate, severe, profound) and 38 with normal cognition (c...

journal_title：Pain

authors： Defrin R,Lotan M,Pick CG

更新日期：2006-10-01 00:00:00

abstract：:The present study aimed to investigate if (1) subcutaneous injection of glutamate induces pain, sensitization and vasomotor responses in humans and (2) if sex differences exist in these responses. Thirty healthy volunteers (men-15 and women-15) were included. Each subject received four subcutaneous injections (0.1ml; ...

journal_title：Pain

authors： Gazerani P,Wang K,Cairns BE,Svensson P,Arendt-Nielsen L

更新日期：2006-10-01 00:00:00

abstract：:Indicators of persistent pain in preterm neonates are poorly defined. In the setting of a double blind, placebo-controlled trial investigating morphine use in ventilated preterm infants (NEOPAIN Trial) we aimed to identify factors that may be useful in assessing persistent pain. Twenty-two babies (morphine 12; placebo...

journal_title：Pain

authors： Boyle EM,Freer Y,Wong CM,McIntosh N,Anand KJ

更新日期：2006-09-01 00:00:00

abstract：:We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty and the effects of a single i.v. preoperative dose of methylprednisolone 125 mg (n=74), parecoxib 40 mg (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks and 1 year after surgery. Response rate a...

journal_title：Pain

authors： Romundstad L,Breivik H,Roald H,Skolleborg K,Romundstad PR,Stubhaug A

更新日期：2006-09-01 00:00:00

abstract：:A randomized, double-blind, placebo-controlled study of low-level laser therapy (LLLT) in 90 subjects with chronic neck pain was conducted with the aim of determining the efficacy of 300 mW, 830 nm laser in the management of chronic neck pain. Subjects were randomized to receive a course of 14 treatments over 7 weeks ...

journal_title：Pain

authors： Chow RT,Heller GZ,Barnsley L

更新日期：2006-09-01 00:00:00

abstract：:The localization of sodium channels (NaChs) change following nerve lesions and this change may contribute to the development of increased pain states. Here we examine the change in distribution of NaChs within the rat infraorbital nerve (ION) two weeks after a combined inflammatory/partial axotomy lesion that results ...

journal_title：Pain

authors： Henry MA,Freking AR,Johnson LR,Levinson SR

更新日期：2006-09-01 00:00:00

abstract：:The nationwide multicenter trials of the German Research Network on Neuropathic Pain (DFNS) aim to characterize the somatosensory phenotype of patients with neuropathic pain. For this purpose, we have implemented a standardized quantitative sensory testing (QST) protocol giving a complete profile for one region within...

journal_title：Pain

authors： Rolke R,Baron R,Maier C,Tölle TR,Treede -DR,Beyer A,Binder A,Birbaumer N,Birklein F,Bötefür IC,Braune S,Flor H,Huge V,Klug R,Landwehrmeyer GB,Magerl W,Maihöfner C,Rolko C,Schaub C,Scherens A,Sprenger T,Valet M,

更新日期：2006-08-01 00:00:00

abstract：:To investigate the pathways of noxious information in the spinal cord in humans, we recorded cortical potentials following the stimulation of A-delta fibers using a YAG laser applied to two cutaneous points on the back at the C7 and Th10 level, 4cm to the right of the vertebral spinous process. A multiple source analy...

journal_title：Pain

authors： Tsuji T,Inui K,Kojima S,Kakigi R

更新日期：2006-08-01 00:00:00

abstract：:Past research has shown that pain catastrophizing contributes to heightened pain experience. The hypothesis advanced in this study was that individuals who score high on measures of pain catastrophizing would also perceive more intense pain in others. The study also examined the role of pain behaviour as a determinant...

journal_title：Pain

authors： Sullivan MJ,Martel MO,Tripp DA,Savard A,Crombez G

更新日期：2006-07-01 00:00:00

abstract：:Osteoarthritis (OA) is a debilitating disease in which primarily weight-bearing joints undergo progressive degeneration. Despite the widespread prevalence of OA in the adult population, very little is known about the factors responsible for the generation and maintenance of OA pain. Vasoactive intestinal peptide (VIP)...

journal_title：Pain

authors： McDougall JJ,Watkins L,Li Z

更新日期：2006-07-01 00:00:00

abstract：:Recent studies showed an enhanced general sensitivity to painful stimuli in adult migraineurs during as well as between attacks. Yet, the influence of a prolonged pain history and potential sex differences has not been studied. We used quantitative sensory testing to examine 25 children with migraine between attacks a...

journal_title：Pain

authors： Zohsel K,Hohmeister J,Oelkers-Ax R,Flor H,Hermann C

更新日期：2006-07-01 00:00:00

abstract：:To determine the incidence of pain related sexual dysfunction 1 year after inguinal herniorrhaphy and to assess the impact pain has on sexual function. In contrast to the well-described about 10% risk of chronic wound related pain after inguinal herniorrhaphy, chronic genital pain, dysejaculation, and sexual dysfuncti...

journal_title：Pain

authors： Aasvang EK,Møhl B,Bay-Nielsen M,Kehlet H

更新日期：2006-06-01 00:00:00

abstract：:Although systemic lidocaine has been shown to suppress postoperative pain in a clinical setting, the mechanisms of action of lidocaine have not been elucidated. The present study was therefore designed to determine the relative contribution of central and peripheral sites to the action of lidocaine on incision-induced...

journal_title：Pain

authors： Kawamata M,Sugino S,Narimatsu E,Yamauchi M,Kiya T,Furuse S,Namiki A

更新日期：2006-05-01 00:00:00

abstract：:In recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources...

journal_title：Pain

authors： Miranda-Cardenas Y,Rojas-Piloni G,Martínez-Lorenzana G,Rodríguez-Jiménez J,López-Hidalgo M,Freund-Mercier MJ,Condés-Lara M

更新日期：2006-05-01 00:00:00

abstract：:The antinociception induced by the intraperitoneal coadministration of combinations of paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, ketoprofen, meloxicam, metamizol, naproxen, nimesulide, parecoxib and piroxicam was studied by isobolographic analysis in the acetic acid abdo...

journal_title：Pain

authors： Miranda HF,Puig MM,Prieto JC,Pinardi G

更新日期：2006-03-01 00:00:00

abstract：:Shoulder pain is common in primary care and has an unfavourable outcome in many patients. Information about predictors of outcome is scarce and inconsistent. The objective of this study was to develop clinical prediction rules for calculating the absolute risk of persistent shoulder symptoms for individual patients, 6...

journal_title：Pain

authors： Kuijpers T,van der Windt DAWM,Boeke JPA,Twisk JWR,Vergouwe Y,Bouter LM,van der Heijden GJMG

更新日期：2006-02-01 00:00:00

abstract：:Accurate pain assessment is the foundation for effective pain management in children. At present, there is no clear consensus regarding the age at which young children are able to appropriately use self-report scales for pain. This study examined young children's ability to use the Faces Pain Scale-Revised; (FPS-R; [H...

journal_title：Pain

authors： Stanford EA,Chambers CT,Craig KD

更新日期：2006-01-01 00:00:00

abstract：:Nitric oxide (NO), synthesised by different isoforms of nitric oxide synthase (NOS), has been linked with the development and maintenance of nociception. We studied the role of the inducible isoform, iNOS, in two different rat pain models with an inflammatory component. iNOS was immunohistochemically detected locally ...

journal_title：Pain

authors： De Alba J,Clayton NM,Collins SD,Colthup P,Chessell I,Knowles RG

更新日期：2006-01-01 00:00:00

abstract：:The effects of cognitive and competing sensory processing tasks on pain perception and as a function of time are only partially understood. To study these effects, we compared the simultaneous effects of noxious heat stimulation (HS), auditory stimulation (AS) (sinusoidally modulated speech-like signal, SMSLS), and a ...

journal_title：Pain

authors： Pud D,Sapir S

更新日期：2006-01-01 00:00:00

abstract：:Nitric oxide (NO) acts as a neurotransmitter or neuromodulator involving in the modulation of thermal and/or inflammatory hyperalgesia. The neuronal nitric oxide synthase (nNOS) is a key enzyme for NO production in normal neuronal tissues, but its functional role in chronic pain remains unclear. The present study comb...

journal_title：Pain

authors： Chu YC,Guan Y,Skinner J,Raja SN,Johns RA,Tao YX

更新日期：2005-12-15 00:00:00

abstract：:Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no m...

journal_title：Pain

authors： Ling B,Authier N,Balayssac D,Eschalier A,Coudore F

更新日期：2005-12-15 00:00:00

abstract：:The aims of this study were threefold. Firstly, to investigate the effect of increasing threat-expectancy on attentional biases towards pain-related words. Secondly, to determine the interaction between threat-expectancy and the effectiveness of two coping strategies on pain threshold and tolerance. Thirdly, to invest...

journal_title：Pain

authors： Boston A,Sharpe L

更新日期：2005-12-15 00:00:00

abstract：:Extracellular signal-regulated kinase (ERK), a mitogen-activated protein kinases (MAPK), transduces a broad range of extracellular stimuli into diverse intracellular responses. Recent studies have showed that ERK activation in the supraspinal level involved in the development of drug dependence, especially in psycholo...

journal_title：Pain

authors： Cao JL,He JH,Ding HL,Zeng YM

更新日期：2005-12-05 00:00:00

abstract：:Evidence has been accumulated suggesting that a dysfunction in pain inhibitory systems, i.e. in 'diffuse noxious inhibitory controls' (DNIC)-like mechanisms, might be-amongst other factors-responsible for the development of anatomically generalized chronic pain like fibromyalgia. The aim of the present study was to lo...

journal_title：Pain

authors： Pielsticker A,Haag G,Zaudig M,Lautenbacher S

更新日期：2005-11-01 00:00:00

abstract：:Orexins are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus, and related to the central control of appetite, arousal, and antinociception. Orexin neurons projected to the tuberomammillary nucleus and orexins may release histamine from the histamine neurons in this nucleus. Histamine i...

journal_title：Pain

authors： Mobarakeh JI,Takahashi K,Sakurada S,Nishino S,Watanabe H,Kato M,Naghdi N,Yanai K

更新日期：2005-11-01 00:00:00

abstract：:Aerobic exercise has been shown to activate endogenous opioid and adrenergic systems and attenuate experimental pain in normal control subjects (NC). In contrast, fibromyalgia (FM) subjects' experimental pain ratings increase after aerobic exercise, suggestive of abnormal pain modulation. In order to determine whether...

journal_title：Pain

authors： Staud R,Robinson ME,Price DD

更新日期：2005-11-01 00:00:00

abstract：:The efficacy of intravenous acetaminophen (1000mg) in the treatment of acute migraine attacks as an alternative to parenteral application of lysine acetylsalicylate or triptans was investigated, using a multi-center, randomized, double-blind, placebo controlled study design. Migraine diagnosis was made according to th...

journal_title：Pain

authors： Leinisch E,Evers S,Kaempfe N,Kraemer C,Sostak P,Jürgens T,Straube A,May A

更新日期：2005-10-01 00:00:00

abstract：:We developed a mouse model of cancer pain to investigate its underlying mechanisms. SCC-7, squamous cell carcinoma (SCC) derived from C3H mice, was inoculated subcutaneously into either the plantar region or thigh in male C3H/Hej mice. Heat and mechanical sensitivity as well as spontaneous behavior were measured at th...

journal_title：Pain

authors： Asai H,Ozaki N,Shinoda M,Nagamine K,Tohnai I,Ueda M,Sugiura Y

更新日期：2005-09-01 00:00:00

abstract：:Mental stress induces endothelial dysfunction, that is a reduction of the post-occlusion brachial artery flow-mediated vasodilation (FMD). This does not occur in subjects highly susceptible to hypnosis (Highs) in either the waking or hypnotic state. The aim of the present experiment was to assess whether endothelial d...

journal_title：Pain

authors： Jambrik Z,Santarcangelo EL,Rudisch T,Varga A,Forster T,Carli G

更新日期：2005-08-01 00:00:00

abstract：:The existence of a pathophysiological link between tonic muscle activity and chronic muscle pain is still being debated. The purpose of this retrospective, controlled study was to evaluate the electromyographic (EMG) activity of masticatory muscles in subjects with different orofacial pain conditions. The temporal and...

journal_title：Pain

authors： Bodéré C,Téa SH,Giroux-Metges MA,Woda A

更新日期：2005-07-01 00:00:00

abstract：:The human palm has a lower heat detection threshold and a higher heat pain threshold than hairy skin. Neurophysiological studies of monkeys suggest that glabrous skin has fewer low threshold heat nociceptors (AMH type 2) than hairy skin. Accordingly, we used a temperature-controlled contact heat evoked potential (CHEP...

journal_title：Pain

authors： Granovsky Y,Matre D,Sokolik A,Lorenz J,Casey KL

更新日期：2005-06-01 00:00:00